HIFU utilizes intersecting beams of ultrasound waves to create a high intensity focal point. When the focus is located in soft tissue, the acoustic energy is absorbed and converted into heat. Beyond a certain threshold, this heat causes thermal coagulation of the tissue resulting in localized cell death. The key advantage of HIFU is that it is noninvasive. It does not require skin puncture and healthy tissue in the ultrasound near Þeld is left undamaged by the treatment. Unfortunately, HIFU has only received approval from the Food and Drug Administration (FDA) for treatment of benign uterine Þbroids, yet HIFU has the potential to treat many different cancers. Needless to say, there are lingering concerns with regard to the safety and efficacy of HIFU.
The objective of this research is to improve the safety and effectiveness of HIFU ablative therapy through automatic feedback control, thereby creating opportunities for its use as a viable cancer treatment. We attest that our proposed work is of such fundamental importance, as it will produce control methods to enable tumor targeting and motion compensation, improve reliability for complete necrosis, and bring about true usability through control automation.